Targeted Treatment for Severe Asthma: The Promise of Biologics

For people with severe asthma, biologic therapies are offering a new lease on life. These specialized treatments go beyond traditional medications to address the specific immune responses that cause chronic asthma symptoms.

Severe asthma involves more than just occasional breathing issues. It means daily symptoms, frequent flare-ups, and a lack of control even with strong medications like inhaled steroids. For these patients, biologics may offer a much more effective solution.

Biologics are advanced treatments that target particular molecules or cells in the immune system that trigger asthma. By focusing on these sources, they calm inflammation, prevent attacks, and improve lung function—all with fewer side effects compared to broad-spectrum treatments.

Some of the biologics currently used to treat severe asthma include:

1. Omalizumab – Helps patients with allergic asthma by neutralizing IgE.

2. Benralizumab – Targets eosinophils, reducing inflammation.

3. Mepolizumab & Reslizumab – Block the IL-5 pathway, also for eosinophilic asthma.

These treatments are administered by injection, either at a clinic or sometimes at home, depending on the plan.

Those using biologic therapies often experience:

• Fewer severe asthma episodes

• Easier breathing and better lung function

• Less need for long-term steroids

• Improved physical and emotional well-being

These outcomes can greatly enhance day-to-day life and reduce emergency care.

Biologics come with some important considerations:

1. High cost: These medications often require insurance approval.

2. Side effects: Injection reactions and minor infections are possible.

3. Need for follow-up: Continued monitoring is needed to ensure success and safety.

Speaking with a specialist helps you weigh the pros and cons before starting treatment.

Biologic therapies are constantly evolving. New research is leading to more types of biologics and better ways to personalize care. Genetic testing and biomarkers may soon guide treatment choices, ensuring the best possible outcome for each patient.

If you or someone you know is living with severe asthma, biologics might be the breakthrough needed for better symptom control and a more active life. Don’t hesitate to speak with a healthcare provider to explore these advanced options.